منابع مشابه
The proteoglycan bikunin has a defined sequence
Proteoglycans are complex glycoconjugates that regulate critical biological pathways in all higher organisms. Bikunin, the simplest proteoglycan, with a single glycosaminoglycan chain, is a serine protease inhibitor used to treat acute pancreatitis. Unlike nucleic acids and proteins, whose synthesis is template driven, Golgi-synthesized glycosaminoglycans are not believed to have predictable or...
متن کاملCharacterization and N-terminal sequence of human platelet proteoglycan.
Human platelet proteoglycan (P.PG) was prepared from a 4 M-guanidinium chloride platelet extract in the presence of proteinase inhibitors. The purification procedure included CsCl-density-gradient centrifugation, DEAE-Sepharose CL-6B ion-exchange chromatography and f.p.l.c. on a Mono Q HR 5/5 column. P.PG was recovered as a polydisperse molecule, but the protein core appeared to be at least 90%...
متن کاملDomain structure and sequence similarities in cartilage proteoglycan.
the length of the polypeptide. In the second (CS2), the glycosaminoglycans occur as clusters separated by gaps. The current view of the aggregating cartilage proteoglycan is thus of a multidomain structure. Because the interaction with hyaluronate is fundamental to the role these molecules play in cartilage, a good deal of attention has been focused on the molecular structure of this domain. Th...
متن کاملMouse aggrecan, a large cartilage proteoglycan: protein sequence, gene structure and promoter sequence.
Seven genomic clones for mouse aggrecan core protein have been isolated including 3 kb of 5'- and 7 kb of 3'-flanking sequences. All exon sequences and their intron boundary sequences in these clones were identified and mapped by DNA sequencing. The gene spans at least 61 kb and contains 18 exons. Exon 1 encodes 5'-untranslated sequence and exon 2 contains a translation start codon, methionine....
متن کاملMolecular cloning and sequence analysis of the cDNA for small proteoglycan II of bovine bone.
The cDNA for the full-length core protein of the small chondroitin sulphate proteoglycan II of bovine bone was cloned and sequenced. A 1.3 kb clone (lambda Pg28) was identified by plaque hybridization with a previously isolated 1.0 kb proteoglycan cDNA clone (lambda Pg20), positively identified previously by polyclonal and monoclonal antibody reactivity and by hybrid-selected translation in vit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular BioSystems
سال: 2012
ISSN: 1742-206X,1742-2051
DOI: 10.1039/c2mb25021g